Topics of the course
Through theoretical and practical sessions, the main aspects related to dengue will be covered: dengue epidemiology, clinical management, diagnosis, virology and immunology, vector control, environmental risk factors and community participation. Important aspects to be discussed are trends of dengue at global level, impact of climate change, new dengue clinical classification, opportunities for diagnosis, impact of virus diversity, immunogenetics, complexity of dengue immunity and pathogenesis, dengue vaccines, integrated surveillance and control, difficulties, options, challenges, economic burden, new options for control, insecticide resistance, the environment, health systems and dengue, among others. Within the framework of the course, the new global initiatives for dengue and the experiences of several countries and geographical regions will be updated.
In the first week, general lectures as well as round tables and symposia on the topics of clinic, emergency response, diagnostic, pathogenesis, vaccines, antiviral drugs, integrated control and emergent arboviruses are also scheduled. Two mini-courses on GIS and dengue and Modeling of transmission and prediction of dengue as well as other activities and meetings will be also organized .
General topics to be covered
Global epidemiological situation.
International initiatives
Integrated dengue surveillance
Viral genome and structure
Viral replication.
Clinical picture and pathology. Clinical management
WHO dengue clinical classification.
PAHO/WHO Dengue Guidelines for clinical management
Dengue diagnostic and laboratory surveillance
Humoral and cellular immune response. Innate immunity
Antibody dependent enhancement (ADE).
Genetic host factors
Pathogenesis and physiopathology
Animal models
Vaccine candidates and antivirals
Vector ecology
Vector dynamic for dengue transmission
Entomological surveillance.
Chemical and biological vector control methods.
Mechanisms of Insecticide Resistance
Social aspects in dengue
Mathematical models for dengue transmission study
Integral Strategy (EGI) for dengue prevention and control
Ecobiosystem approach for dengue control and prevention
The community role in dengue control.
Cost/effectivity of dengue control activities
Emergency management for outbreak control
Cuban experience: surveillance and control
Climate change and dengue
Emergent arboviruses