Thursday, August 11
8:30 Symposium: Dengue Pathogenesis. G. García & K. Hirayama. The virus in dengue pathogenesis. R Rodriguez-Roche. Influence of the pre-existing dengue memory T cell immune response in secondary and tertiary infections. B Sierra
Cellular immune response in DHF G. Screaton. Polymorphic immune response genes & susceptibility to dengue disease. A. B. Perez. An integral view of dengue pathogenesis. S. Halstead. Discussion
10:30 COFFEE
11:00 Symposium: Update in dengue diagnostic. S. Vazquez & R. Peeling. NS1 protein, usefulness in early dengue diagnostic. P. Young. Application of molecular biology to dengue diagnostic. D. Rosario. Serological markers in dengue infection S. Vazquez
Evaluation of diagnostic tests for infectious diseases: the example of dengue. R. Peeling. Lecture TBD. Discussion
13:00 LUNCH
14:00 Symposium: Antivirals for dengue. P Young & R. Ramirez. (Room 7). Viral targets & the pathway to delivery of drugs in the clinic – Role for the DTN. P. Young.The importance of structures and assays for structure-based drug design. ?? TBD
Some real examples – fusion/protease/polymerase inhibitors. S. Vasudevan. Cuban studies. G. Chinea. Search for inhibitor compounds of dengue virus NS3 activities. R. da Silva
Small-molecule inhibitors that selectively block flavivirus methyltransferase. S. Pheng. In vivo testing – animal (mouse) models. E. Harris. Clinical trials. ??? Pharmaceutical perspective ????
14:00 Symposium:. How address emergency dengue situations. J L San Martín, Cuba, Brazil, P. Rico, Peru. Participants to be defined
16:00 COFFEE
16:30 Round table: Chikungunya & other emergent arboviruses. M. Pupo & D. Enria. Overview of emergent arboviruses in the American region. M. Pupo. Emerging arbovirus circulation in Argentina. D. Enria. Emerging arbovirus circulation in Brazil. TBD ¿??
Chikungunya – lessons learnt from SE Asia C. Hapuarachchi. Guidelines for the preparation & response to Chikungunya introduction in the American region. R. Montoya